Cyclin D1 gene polymorphism as a risk factor for squamous cell carcinoma of the upper aerodigestive system in non-alcoholics.

@article{Nishimoto2004CyclinDG,
  title={Cyclin D1 gene polymorphism as a risk factor for squamous cell carcinoma of the upper aerodigestive system in non-alcoholics.},
  author={In{\^e}s Nobuko Nishimoto and N{\'i}dia Alice Pinheiro and S{\'i}lvia Regina Rogatto and Andr{\'e} Lopes Carvalho and Andrew J G Simpson and Ot{\'a}via Lu{\'i}sa Silva Damas Caballero and Luiz Paulo Kowalski},
  journal={Oral oncology},
  year={2004},
  volume={40 6},
  pages={
          604-10
        }
}
Squamous cell carcinoma of the upper aerodigestive tract (UADT) is associated with environmental factors, especially tobacco and alcohol consumption. Genetic factors, including cyclin D1 (CCND1) polymorphism have been suggested to play an important role in tumorigenesis and progression of UADT cancer. To investigate the relationship between CCND1 polymorphism on susceptibility for UADT cancers, 147 cancer and 135 non-cancer subjects were included in this study. CCND1 genotype at codon 242(G870A… CONTINUE READING
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