Cyclin D1 gene amplification and protein expression in benign breast disease and breast carcinoma.

@article{Zhu1998CyclinDG,
  title={Cyclin D1 gene amplification and protein expression in benign breast disease and breast carcinoma.},
  author={Xuegong Zhu and Warren Hartwick and Thomas Rohan and Rita A Kandel},
  journal={Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc},
  year={1998},
  volume={11 11},
  pages={1082-8}
}
Cyclin D1 plays a critical role in regulating cell-cycle progression. Gene amplification and protein overexpression of cyclin D1 have been detected in breast cancer but little is known concerning whether these changes occur in normal breast tissue and in breast lesions associated with increased risk of development of invasive breast cancer. We looked for cyclin D1 gene amplification and protein overexpression in 30 cases of benign breast disease (16 epithelial hyperplasias without atypia and 14… CONTINUE READING
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