Cyclin D1 gene G870A polymorphism predicts response to neoadjuvant radiotherapy and prognosis in rectal cancer.

@article{HoPunCheung2007CyclinDG,
  title={Cyclin D1 gene G870A polymorphism predicts response to neoadjuvant radiotherapy and prognosis in rectal cancer.},
  author={Alexandre Ho-Pun-Cheung and Eric Ass{\'e}nat and Simon Th{\'e}z{\'e}nas and Fr{\'e}d{\'e}ric Bibeau and P Rouanet and David Azria and Dominic Cellier and Jean Grenier and Marc Ychou and Pierre S{\'e}nesse and Evelyne Lopez-Crapez},
  journal={International journal of radiation oncology, biology, physics},
  year={2007},
  volume={68 4},
  pages={1094-101}
}
PURPOSE To investigate whether CCND1 genetic variations associated with a constitutive nuclear protein may influence either the pathologic response to preoperative RT or the prognosis in a series of rectal cancer patients. METHODS AND MATERIALS Seventy rectal cancer patients treated by neoadjuvant radiotherapy were included in the study. CCND1 exon 5 mutations were screened, and the G870A polymorphism was assessed for correlation with clinical variables, tumor response, and patient outcome… CONTINUE READING
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