Cyclin D1 expression in astrocytomas is associated with cell proliferation activity and patient prognosis.

@article{Sallinen1999CyclinDE,
  title={Cyclin D1 expression in astrocytomas is associated with cell proliferation activity and patient prognosis.},
  author={S L Sallinen and P K Sallinen and Juha Kononen and Kirsi Syrj{\"a}koski and Nina N. Nupponen and Immo Rantala and Pauli Helen and Heikki J. Helin and Hannu Kalervo Haapasalo},
  journal={The Journal of pathology},
  year={1999},
  volume={188 3},
  pages={289-93}
}
An important positive regulator of the cell cycle, cyclin D1, is often amplified and overexpressed in malignancies. Cyclin D1 aberrations were analysed in grade II-IV astrocytomas by fluorescence in situ hybridization (FISH), mRNA in situ hybridization and immunohistochemistry. Proliferation activity was determined by Ki-67(MIB-1) immunolabelling and mitotic counting. High cyclin D1 expression was observed in grade IV astrocytomas (grades II-III versus grade IV; mRNA expression: p<0.001… CONTINUE READING

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