Cyclin D1 and retinoblastoma gene expression in human breast carcinoma: correlation with tumour proliferation and oestrogen receptor status.

@article{Jares1997CyclinDA,
  title={Cyclin D1 and retinoblastoma gene expression in human breast carcinoma: correlation with tumour proliferation and oestrogen receptor status.},
  author={Pedro Jares and Mar{\'i}a Jes{\'u}s Rey and P L Fern{\'a}ndez and El{\'i}as Campo and Alfons Nadal and Miguel Bethencourt Mu{\~n}oz and Carme Mallofr{\'e} and Jaume Muntan{\'e} and Iracema Nayach and Jordi Vila Estape and Antonio Cardesa},
  journal={The Journal of pathology},
  year={1997},
  volume={182 2},
  pages={160-6}
}
Cyclin D1 (CCND1) and retinoblastoma (Rb) genes are cell cycle regulators which are altered in some breast carcinomas. However, the possible cooperation between CCND1 and Rb, as well as the influence and coincidence of their abnormalities in the proliferative capacity of mammary carcinoma cells in vivo, is still unknown. In order to assess both the significance of the CCND1 gene and Rb alterations in breast carcinomas and their relationship with the proliferative capacity of the tumours and… CONTINUE READING

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