• Biology, Medicine
  • Published in Breast Cancer Research 2001
  • DOI:10.1186/bcr411

Cyclin D1 and mammary carcinoma: new insights from transgenic mouse models

@article{Sutherland2001CyclinDA,
  title={Cyclin D1 and mammary carcinoma: new insights from transgenic mouse models},
  author={Robert Lyndsay Sutherland and Elizabeth A. Musgrove},
  journal={Breast Cancer Research},
  year={2001},
  volume={4},
  pages={14 - 17}
}
Cyclin D1 is one of the most commonly overexpressed oncogenes in breast cancer, with 45–50% of primary ductal carcinomas overexpressing this oncoprotein. Targeted deletion of the gene encoding cyclin D1 demonstrates an essential role in normal mammary gland development while transgenic studies provide evidence that cyclin D1 is a weak oncogene in mammary epithelium. In a recent exciting development, Yu et al. demonstrate that cyclin D1-deficient mice are resistant to mammary carcinomas induced… CONTINUE READING

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