Cyclin D1 and estrogen receptor messenger RNA levels are positively correlated in primary breast cancer.

@article{Hui1996CyclinDA,
  title={Cyclin D1 and estrogen receptor messenger RNA levels are positively correlated in primary breast cancer.},
  author={Rina Hui and Ann L. Cornish and Richard A. McClelland and John F. R. Robertson and Roger W. Blamey and Elizabeth A. Musgrove and Robert Ian Nicholson and Robert Lyndsay Sutherland},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={1996},
  volume={2 6},
  pages={923-8}
}
The CCND1 gene, encoding the cell cycle regulatory protein cyclin D1, maps to chromosome 11q13, a locus that is amplified in about 13% of breast cancers. Because several studies have indicated a relationship between 11q13 amplification and markers of phenotype including estrogen receptor (ER) status, we tested the relationship between CCND1 and ER gene expression in 364 primary breast cancers using Northern blot analysis. Seventy-three % of samples were positive for ER mRNA, and cyclin D1 mRNA… CONTINUE READING

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EstrogensContraindicated with diseaseMammary Neoplasms
Cyclin D1 and estrogen receptor messenger RNA levels are positively correlated in primary breast cancer .
Because several studies have indicated a relationship between 11q13 amplification and markers of phenotype including estrogen receptor ( ER ) status , we tested the relationship between CCND1 and ER gene expression in 364 primary breast cancers using Northern blot analysis .
Cyclin D1 and estrogen receptor messenger RNA levels are positively correlated in primary breast cancer .
Because several studies have indicated a relationship between 11q13 amplification and markers of phenotype including estrogen receptor ( ER ) status , we tested the relationship between CCND1 and ER gene expression in 364 primary breast cancers using Northern blot analysis .
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