Cyclin D1 and MIB-1 immunohistochemistry in ependymomas: a study of 41 cases.

@article{Prayson1998CyclinDA,
  title={Cyclin D1 and MIB-1 immunohistochemistry in ependymomas: a study of 41 cases.},
  author={Richard A. Prayson},
  journal={American journal of clinical pathology},
  year={1998},
  volume={110 5},
  pages={
          629-34
        }
}
The molecular genetic events involved in the development of ependymal neoplasms are not well understood. This study retrospectively examines 41 ependymomas; in all tumors the cyclin D1 labeling index (LI) (percent of positive immunostaining tumor cells) was correlated with MIB-1 LI and outcome. The study included 41 patients (25 males and 16 females) ranging in age from 1.5 to 70 years (mean, 30.7 years). Twenty-five patients underwent a subtotal resection or biopsy, and 16 underwent a gross… CONTINUE READING
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