Cyclin D1-CDK4 Controls Glucose Metabolism Independently of Cell Cycle Progression

@inproceedings{Lee2014CyclinDC,
  title={Cyclin D1-CDK4 Controls Glucose Metabolism Independently of Cell Cycle Progression},
  author={Yoonjin Lee and John E. Dominy and Yoon Jong Choi and Michael J Jurczak and Nicola J. Tolliday and Jo{\~a}o Paulo Grabriel Camporez and Helen Chim and Ji Hong Lim and Hai-Bin Ruan and Xiaoyong Yang and Francisca Vazquez and Piotr Sicinski and Gerald I Shulman and Pere B. Puigserver},
  booktitle={Nature},
  year={2014}
}
Insulin constitutes a principal evolutionarily conserved hormonal axis for maintaining glucose homeostasis; dysregulation of this axis causes diabetes. PGC-1α (peroxisome-proliferator-activated receptor-γ coactivator-1α) links insulin signalling to the expression of glucose and lipid metabolic genes. The histone acetyltransferase GCN5 (general control non-repressed protein 5) acetylates PGC-1α and suppresses its transcriptional activity, whereas sirtuin 1 deacetylates and activates PGC-1… CONTINUE READING
BETA
Tweets
This paper has been referenced on Twitter 17 times. VIEW TWEETS

Citations

Publications citing this paper.
SHOWING 1-10 OF 63 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 34 REFERENCES

Phase I study of PD 0332991, a cyclin-dependent kinase inhibitor, administered in 3-week cycles (Schedule 2/1)

  • GK Schwartz
  • British journal of cancer
  • 2011

Similar Papers

Loading similar papers…