Cyclin D and retinoblastoma gene product expression in actinic keratosis and cutaneous squamous cell carcinoma in relation to p53 expression.

@article{Bito1995CyclinDA,
  title={Cyclin D and retinoblastoma gene product expression in actinic keratosis and cutaneous squamous cell carcinoma in relation to p53 expression.},
  author={Toshinori Bito and Masato Ueda and N. U. Ahmed and Tohru Nagano and Masamitsu Ichihashi},
  journal={Journal of cutaneous pathology},
  year={1995},
  volume={22 5},
  pages={427-34}
}
Abnormality of the molecules regulating the cell cycle has been shown to lead cells to transformation. Recently, overexpression of cyclin D protein, one of the G1 cyclins, and the abnormality of the retinoblastoma gene have been found in various human cancers. We analyzed the expression of cyclin D, retinoblastoma gene product (pRB) and p53 in actinic keratoses (AKs) and cutaneous squamous cell carcinomas (SCCs) by immunohistochemistry to elucidate the role of these molecules in keratinocyte… CONTINUE READING

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