Cyclin D 3 is a target gene of t ( 6 ; 14 ) ( p 21 . 1 ; q 32 . 3 ) of mature B-cell malignancies

  title={Cyclin D 3 is a target gene of t ( 6 ; 14 ) ( p 21 . 1 ; q 32 . 3 ) of mature B-cell malignancies},
  author={Takashi Sonoki and Lana Harder and Douglas E. Horsman and Loraine Karran and Izumi Taniguchi and Tony G. Willis and Stefan Gesk and Doris Steinemann and Emanuele Zucca and Brigitte Schlegelberger and Francesc Sol{\'e} and Andrew J. Mungall and Randy D. Gascoyne and Reiner Siebert and Martin J. S. Dyer},
  • Takashi Sonoki, Lana Harder, +12 authors Martin J. S. Dyer
  • Published 2001
Chromosomal translocation t(6;14)(p21.1; q32.3) has been reported as a rare but recurrent event not only in myeloma and plasma cell leukemia but also in diffuse large B-cell non-Hodgkin lymphoma (B-NHL) (diffuse large B-cell lymphoma [DLBCL]) and splenic lymphoma with villous lymphocytes (SLVL); however, the nature of the target gene(s) has not been determined. This study identified t(6; 14)(p21.1;q32.3) in 3 cases of transformed extranodal marginal zone B-NHL, in 1 case of SLVL, and in 1 case… CONTINUE READING
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The role of immunoglobulin translocations in the pathogenesis of B-cell malignancies

  • TG Willis, Dyer MJS
  • Blood
  • 2000

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