Cyclin D 1 overexpression correlates with poor tumor differentiation and prognosis in gastric cancer
@inproceedings{Shan2017CyclinD1, title={Cyclin D 1 overexpression correlates with poor tumor differentiation and prognosis in gastric cancer}, author={Yan Shen Shan and Hui-Ping Hsu and Ming Derg Lai and Yu-Hsuan Hung and Chih-Yang Wang and Meng-Chi Yen and Yi Chen}, year={2017} }
Overexpression of cyclin D is associated with the molecular tumorigenesis of gastric cancer. The purpose of the present study was to investigate the expression of cyclin D in human gastric cancer and to determine the potential correla‐ tions between cyclin D expression and clinicopathological characteristics of specific histological types, as well as its prognostic significance. In the present study, the expression of the cyclin D1 (CCND1), cyclin D2 (CCND2) and cyclin D3 (CCND3) genes in…
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8 Citations
Cyclin D1 and Clinicopathological Characteristics of Gastric Cancer
- Medicine
- 2021
This cross-sectional study used medical records and paraffin blocks of gastric cancer patients at Cipto Mangunkusumo General Hospital, Jakarta, in 2015–2020 to determine the relationship between cyclin D1 expression and clinicopathological features in Gastric cancer.
Prognostic Significance of Tripartite Motif Containing 16 Expression in Patients with Gastric Cancer
- MedicineAsian Pacific journal of cancer prevention : APJCP
- 2021
A tumor suppressive role for TRIM16 in gastric cancer is suggested and it is proposed as a potential candidate for GC prognosis and multivariate analysis did not support any correlation.
High expression level of CXCL1/GROα is linked to advanced stage and worse survival in uterine cervical cancer and facilitates tumor cell malignant processes
- Biology, MedicineBMC cancer
- 2022
The current study demonstrated that CXCL1 was expressed in HeLa UCC cells, PHM1-41 human immortalized cervical stromal cells, as well as cervical tissues, with UCC tissues having an evidently high level of CxCL1.
Role of TROP2, Cyclin D1 and FOXP3 in Bladder Carcinoma in Egyptian Patients: An Immunohistochemical Study
- Medicine, BiologyInternational Journal of Cancer and Biomedical Research
- 2020
Evaluated role of TROP2, CYCLIN D1, FOXP3 and their relationship with the established clinico-pathological parameters and overall survival of bladder cancer in Egyptian patients found them to be promising potential biomarkers for identifying patients with poor prognostic factors in bladder cancer serving as potential targets for cancer therapy.
Expression levels of sonic hedgehog pathway genes and their targets are upregulated in early clear cell renal cell carcinoma
- BiologyInternational journal of molecular medicine
- 2022
The results of the present study suggested that SHH signaling may be involved in the early development of ccRCC, and the expression levels of CCND1 and VEGFA may serve as prognostic factors of this disease.
The Regulation of Cyclins and Cyclin-Dependent Kinases in the Development of Gastric Cancer
- BiologyInternational journal of molecular sciences
- 2023
The evidence of molecules acting as regulators of both Cyclins and CDKs, i.e., upstream regulators either activating or inhibiting Cyclin-dependent kinases, is compiled to act as an extensive resource for developing new hypotheses for future studies.
Cyclins and cyclin-dependent kinases: from biology to tumorigenesis and therapeutic opportunities
- BiologyJournal of Cancer Research and Clinical Oncology
- 2022
The present review aimed to take a look at the biology of CDKs and then magnify their contribution to tumorigenesis to reach a consensus on the application of these inhibitors in clinical settings.
Anticancer mechanisms of phytochemical compounds: focusing on epigenetic targets
- Biology, ChemistryEnvironmental Science and Pollution Research
- 2021
Pharmacodynamic actions of natural epidrugs belonging to cannabinoids, carotenoids, chalcones, fatty acids, lignans, polysaccharides, saponins, secoiridoids, steroids, tannins, tanshinones, and other chemical classes are reported and highlighted.
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