• Corpus ID: 12072131

Cyclin D 1 overexpression correlates with poor tumor differentiation and prognosis in gastric cancer

  title={Cyclin D 1 overexpression correlates with poor tumor differentiation and prognosis in gastric cancer},
  author={Yan Shen Shan and Hui-Ping Hsu and Ming Derg Lai and Yu-Hsuan Hung and Chih-Yang Wang and Meng-Chi Yen and Yi Chen},
Overexpression of cyclin D is associated with the molecular tumorigenesis of gastric cancer. The purpose of the present study was to investigate the expression of cyclin D in human gastric cancer and to determine the potential correla‐ tions between cyclin D expression and clinicopathological characteristics of specific histological types, as well as its prognostic significance. In the present study, the expression of the cyclin D1 (CCND1), cyclin D2 (CCND2) and cyclin D3 (CCND3) genes in… 
8 Citations

Figures and Tables from this paper

Cyclin D1 and Clinicopathological Characteristics of Gastric Cancer

This cross-sectional study used medical records and paraffin blocks of gastric cancer patients at Cipto Mangunkusumo General Hospital, Jakarta, in 2015–2020 to determine the relationship between cyclin D1 expression and clinicopathological features in Gastric cancer.

Prognostic Significance of Tripartite Motif Containing 16 Expression in Patients with Gastric Cancer

A tumor suppressive role for TRIM16 in gastric cancer is suggested and it is proposed as a potential candidate for GC prognosis and multivariate analysis did not support any correlation.

High expression level of CXCL1/GROα is linked to advanced stage and worse survival in uterine cervical cancer and facilitates tumor cell malignant processes

The current study demonstrated that CXCL1 was expressed in HeLa UCC cells, PHM1-41 human immortalized cervical stromal cells, as well as cervical tissues, with UCC tissues having an evidently high level of CxCL1.

Role of TROP2, Cyclin D1 and FOXP3 in Bladder Carcinoma in Egyptian Patients: An Immunohistochemical Study

Evaluated role of TROP2, CYCLIN D1, FOXP3 and their relationship with the established clinico-pathological parameters and overall survival of bladder cancer in Egyptian patients found them to be promising potential biomarkers for identifying patients with poor prognostic factors in bladder cancer serving as potential targets for cancer therapy.

Expression levels of sonic hedgehog pathway genes and their targets are upregulated in early clear cell renal cell carcinoma

The results of the present study suggested that SHH signaling may be involved in the early development of ccRCC, and the expression levels of CCND1 and VEGFA may serve as prognostic factors of this disease.

The Regulation of Cyclins and Cyclin-Dependent Kinases in the Development of Gastric Cancer

The evidence of molecules acting as regulators of both Cyclins and CDKs, i.e., upstream regulators either activating or inhibiting Cyclin-dependent kinases, is compiled to act as an extensive resource for developing new hypotheses for future studies.

Cyclins and cyclin-dependent kinases: from biology to tumorigenesis and therapeutic opportunities

The present review aimed to take a look at the biology of CDKs and then magnify their contribution to tumorigenesis to reach a consensus on the application of these inhibitors in clinical settings.

Anticancer mechanisms of phytochemical compounds: focusing on epigenetic targets

Pharmacodynamic actions of natural epidrugs belonging to cannabinoids, carotenoids, chalcones, fatty acids, lignans, polysaccharides, saponins, secoiridoids, steroids, tannins, tanshinones, and other chemical classes are reported and highlighted.



Expression and possible role of cyclin D3 in human pancreatic adenocarcinoma.

Results suggest thatcyclin D3, as well as cyclin D1, plays a role in the progression, including cell proliferating activity, of pancreatic adenocarcinoma.

Cyclin D2, but not cyclin D1, overexpression closely correlates with gastric cancer progression and prognosis

Results indicate that cyclin D2 up‐regulation plays an important role in the progression and prognosis of gastric cancer independently of cdk4, whereas Cyclin D1 overexpression does not.

Cyclin D1 expression and retinoblastoma gene protein (pRB) expression in esophageal squamous cell carcinoma

In 107 surviving patients who underwent curative operation, co-expressed pRB and cyclin D1 were correlated with unfavorable prognosis and high cancer recurrence rate, and results suggest that overexpression of cyclIn D1 may suppress pRB function, and that combined analysis of p RB andcyclin D 1 may be a useful parameter of patient prognosis in ESCC.

Overexpression of cyclin D1 in human pancreatic carcinoma is associated with poor prognosis.

In comparison to normal pancreas, Southern blot analyses revealed amplification of the cyclin D1 coding gene in 25% of the cases, whereas with reverse transcription-PCR, overexpression of mRNA was observed in 82% of of the examined tissues.

Cyclin D1 expression in invasive breast cancer. Correlations and prognostic value.

Cyclin D1 is mainly overexpressed in the well differentiated and lobular types of invasive breast cancer and is strongly associated with estrogen receptor positivity and it is negatively correlated with the proliferation marker mitoses count and with the differentiation markers nuclear area and nuclear volume.

Inactivation of cyclin D2 gene in prostate cancers by aberrant promoter methylation.

It is indicated that methylation of Cyclin D2 in prostate cancers correlates with clinicopathological features of poor prognosis and these findings are of biological and potential clinical importance.

Prognostic value of differential CCND1 expression in patients with resected gastric adenocarcinoma

CCND1 may be used as a prognostic biomarker for patients with RGA and Cox multivariate analyses confirmed that high CCND1 expression was related with poor prognosis in both treatment groups.

Cancers Is Associated with Promoter Hypermethylation Loss of Cyclin D 2 Expression in the Majority of Breast Updated

The results suggest that loss of cyclin D2 expression is associated with the evolution of breast cancer.

Absence of cyclin D2 expression is associated with promoter hypermethylation in gastric cancer

It is shown that cyclin D2 hypermethylation is associated with loss of cyclinD2 expression in a subset of gastric cancers, which may suggest an alternative gastric carcinogenesis pathway in the absence of cyclIn D2 expression.