Cyclin Cln3p links G1 progression to hyphal and pseudohyphal development in Candida albicans.

@article{Bachewich2005CyclinCL,
  title={Cyclin Cln3p links G1 progression to hyphal and pseudohyphal development in Candida albicans.},
  author={Catherine Bachewich and Malcolm Whiteway},
  journal={Eukaryotic cell},
  year={2005},
  volume={4 1},
  pages={
          95-102
        }
}
G1 cyclins coordinate environmental conditions with growth and differentiation in many organisms. In the pathogen Candida albicans, differentiation of hyphae is induced by environmental cues but in a cell cycle-independent manner. Intriguingly, repressing the G1 cyclin Cln3p under yeast growth conditions caused yeast cells to arrest in G1, increase in size, and then develop into hyphae and pseudohyphae, which subsequently resumed the cell cycle. Differentiation was dependent on Efg1p, Cph1p… CONTINUE READING

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