Cyclin B-dependent kinase 1 regulates human TRF1 to modulate the resolution of sister telomeres

@inproceedings{McKerlie2011CyclinBK,
  title={Cyclin B-dependent kinase 1 regulates human TRF1 to modulate the resolution of sister telomeres},
  author={Megan A. McKerlie and Xu-Dong Zhu},
  booktitle={Nature communications},
  year={2011}
}
Cyclin B-Cdk1 is a key mediator of mitotic entry; however, little is known about its role in the separation of sister chromatids. Here we report that upon mitotic entry, Cdk1 specifically phosphorylates threonine 371 of TRF1, a telomere binding protein implicated in the regulation of sister telomere cohesion. Such phosphorylation is removed in late mitosis when Cdk1 activity is inhibited, indicative of a tight regulation of T371 phosphorylation. We show that T371 phosphorylation by Cdk1 keeps… CONTINUE READING
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