Cyclin B/cdc2 induces c-Mos stability by direct phosphorylation in Xenopus oocytes.

@article{Castro2001CyclinBI,
  title={Cyclin B/cdc2 induces c-Mos stability by direct phosphorylation in Xenopus oocytes.},
  author={Antoni Castro and Marion Peter and Laura Magnaghi-Jaulin and Suzanne Vigneron and Simon Galas and Thierry Lorca and J-C. Labb{\'e}},
  journal={Molecular biology of the cell},
  year={2001},
  volume={12 9},
  pages={
          2660-71
        }
}
The c-Mos proto-oncogene product plays an essential role during meiotic divisions in vertebrate eggs. In Xenopus, it is required for progression of oocyte maturation and meiotic arrest of unfertilized eggs. Its degradation after fertilization is essential to early embryogenesis. In this study we investigated the mechanisms involved in c-Mos degradation. We present in vivo evidence for ubiquitin-dependent degradation of c-Mos in activated eggs. We found that c-Mos degradation is not directly… CONTINUE READING
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