Cyclin A2 transcriptional regulation: modulation of cell cycle control at the G1/S transition by peripheral cues.

@article{Blanchard2000CyclinAT,
  title={Cyclin A2 transcriptional regulation: modulation of cell cycle control at the G1/S transition by peripheral cues.},
  author={J M Blanchard},
  journal={Biochemical pharmacology},
  year={2000},
  volume={60 8},
  pages={1179-84}
}
Several types of cyclins have been identified and among these, cyclin A2 is synthesized in somatic cells at the onset of DNA synthesis as well as during the G2/M transition associated with cyclin-dependent protein kinases 1 and 2. Modulation of cyclin A transcription is due to the interplay between a cell cycle-dependent periodic relief of a transcriptional repression and signals transduced through adenosine 3',5'-cyclic monophosphate, transforming growth factor-beta, and the integrin-mediated… CONTINUE READING

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