Cyclin A2, a novel regulator of EMT

@article{Bendris2014CyclinAA,
  title={Cyclin A2, a novel regulator of EMT},
  author={Nawal Bendris and Caroline Tsui Yee Cheung and Hon S Leong and John D. Lewis and Ann F. Chambers and Olivier J. Blanchard and B{\'e}n{\'e}dicte Lemmers},
  journal={Cellular and Molecular Life Sciences},
  year={2014},
  volume={71},
  pages={4881-4894}
}
Our previous work showed that Cyclin A2 deficiency promotes cell invasion in fibroblasts. Given that the majority of cancers emerge from epithelia, we explored novel functions for Cyclin A2 by depleting it in normal mammary epithelial cells. This caused an epithelial to mesenchymal transition (EMT) associated with loss of cell-to-cell contacts, decreased E-Cadherin expression and increased invasive properties characterized by a reciprocal regulation of RhoA and RhoC activities, where RhoA… CONTINUE READING
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