Cyclin A is required at two points in the human cell cycle.

@article{Pagano1992CyclinAI,
  title={Cyclin A is required at two points in the human cell cycle.},
  author={Michele Pagano and Rainer Pepperkok and Fulvia Verde and Wilhelm Ansorge and Giulio F Draetta},
  journal={The EMBO journal},
  year={1992},
  volume={11 3},
  pages={961-71}
}
Cyclins play a fundamental role in regulating cell cycle events in all eukaryotic cells. The human cyclin A gene was identified as the site of integration of hepatitis B virus in a hepatocarcinoma cell line; in addition, cyclin A is associated with the E2F transcription factor in a complex which is dissociated by the E1A oncogene product. Such findings suggest that cyclin A is a target for oncogenic signals. We have now found that DNA synthesis and entry into mitosis are inhibited in human… CONTINUE READING
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