Cyclin A is required at two points in the human cell cycle.

  title={Cyclin A is required at two points in the human cell cycle.},
  author={Michele Pagano and Rainer Pepperkok and Fulvia Verde and Wilhelm Ansorge and Giulio F Draetta},
  journal={The EMBO journal},
  volume={11 3},
Cyclins play a fundamental role in regulating cell cycle events in all eukaryotic cells. The human cyclin A gene was identified as the site of integration of hepatitis B virus in a hepatocarcinoma cell line; in addition, cyclin A is associated with the E2F transcription factor in a complex which is dissociated by the E1A oncogene product. Such findings suggest that cyclin A is a target for oncogenic signals. We have now found that DNA synthesis and entry into mitosis are inhibited in human… CONTINUE READING
Highly Influential
This paper has highly influenced 21 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS


Publications citing this paper.
Showing 1-10 of 436 extracted citations

Cyclin A2: a genuine cell cycle regulator?

Biomolecular concepts • 2012
View 8 Excerpts
Highly Influenced

The Roles of Cyclin A2, B1, and B2 in Early and Late Mitotic Events

Molecular biology of the cell • 2010
View 7 Excerpts
Highly Influenced

Acute myocardial infarction induced functional cardiomyocytes to re-enter the cell cycle.

American journal of translational research • 2013
View 4 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…