Cyclin A in cell cycle control and cancer

@article{Yam2002CyclinAI,
  title={Cyclin A in cell cycle control and cancer},
  author={C. Yam and T. Fung and R. Poon},
  journal={Cellular and Molecular Life Sciences CMLS},
  year={2002},
  volume={59},
  pages={1317-1326}
}
Abstract. Cyclin A is particularly interesting among the cyclin family because it can activate two different cyclin-dependent kinases (CDKs) and functions in both S phase and mitosis. An embryonic form of cyclin A that is only essential for spermatogenesis is also present in some organisms. In S phase, phosphorylation of components of the DNA replication machinery such as CDC6 by cyclin A-CDK is believed to be important for initiation of DNA replication and to restrict the initiation to only… Expand
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