Cyclin A-Cdk1 regulates the origin firing program in mammalian cells.

@article{Katsuno2009CyclinAR,
  title={Cyclin A-Cdk1 regulates the origin firing program in mammalian cells.},
  author={Yuko Katsuno and Ayumi Suzuki and Kazuto Sugimura and Katsuzumi Okumura and Doaa Hussien Zineldeen and Midori Shimada and Hiroyuki Niida and Takeshi Mizuno and Fumio Hanaoka and Makoto Nakanishi},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2009},
  volume={106 9},
  pages={3184-9}
}
Somatic mammalian cells possess well-established S-phase programs with specific regions of the genome replicated at precise times. The ATR-Chk1 pathway plays a central role in these programs, but the mechanism for how Chk1 regulates origin firing remains unknown. We demonstrate here the essential role of cyclin A2-Cdk1 in the regulation of late origin firing. Activity of cyclin A2-Cdk1 was hardly detected at the onset of S phase, but it was obvious at middle to late S phase under unperturbed… CONTINUE READING

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