Cyclin A/cdk2 coordinates centrosomal and nuclear mitotic events

  title={Cyclin A/cdk2 coordinates centrosomal and nuclear mitotic events},
  author={Laurens de Boer and Vanessa Oakes and Heather Beamish and Nichole Giles and Frankie Stevens and Maria J Somodevilla-Torres and Cyrus V. Desouza and Brian G Gabrielli},
Cyclin A/cdk2 has a role in progression through S phase, and a large pool is also activated in G2 phase. Here we report that this G2 phase pool regulates the timing of progression into mitosis. Knock down of cyclin A by siRNA or addition of a specific cdk2 small molecule inhibitor delayed entry into mitosis by delaying cells in G2 phase. The G2 phase-delayed cells contained elevated levels of inactive cyclin B/cdk1. However, increased microtubule nucleation at the centrosomes was observed, and… CONTINUE READING


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Phosphorylation of CDC 25 B by AuroraA at the centrosome contributes to the G 2M transition

  • S Dutertre, M Cazales, C Froment, V Trabut, C Dozier
  • J Cell Sci
  • 2004
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