Cyclin A/Cdk2 complexes regulate activation of Cdk1 and Cdc25 phosphatases in human cells

@article{Mitra2004CyclinAC,
  title={Cyclin A/Cdk2 complexes regulate activation of Cdk1 and Cdc25 phosphatases in human cells},
  author={Jayashree Mitra and Greg H. Enders},
  journal={Oncogene},
  year={2004},
  volume={23},
  pages={3361-3367}
}
  • Jayashree Mitra, Greg H. Enders
  • Published in Oncogene 2004
  • Biology, Medicine
  • Mitotic entry, a critical decision point for maintaining genetic stability, is governed by the cyclin B/Cyclin dependent kinase 1 (Cdc2) complex. In Xenopus oocytes and early embryos, accumulation of cyclin B activates Cdk1, which then phosphorylates and activates the positive regulator Cdc25 in an autocatalytic feedback loop. However, cyclin B levels do not increase as some human cells approach mitosis, and the key factors regulating Cdk1 activation in human cells are unknown. We report here… CONTINUE READING

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