Cyclin‐dependent protein kinases: Key regulators of the eukaryotic cell cycle

@article{Nigg1995CyclindependentPK,
  title={Cyclin‐dependent protein kinases: Key regulators of the eukaryotic cell cycle},
  author={Erich A. Nigg},
  journal={BioEssays},
  year={1995},
  volume={17}
}
  • E. Nigg
  • Published 1 June 1995
  • Biology, Medicine
  • BioEssays
Passage through the cell cycle requires the successive activation of different cyclin‐dependent protein kinases (CDKs). These enzymes are controlled by transient associations with cyclin regulatory subunits, binding of inhibitory polypeptides and reversible phosphorylation reactions. To promote progression towards DNA replication, CDK/cyclin complexes phosphorylate proteins required for the activation of genes involved in DNA synthesis, as well as components of the DNA replication machinery… Expand
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