Cyclin/PCNA is the auxiliary protein of DNA polymerase-δ

  title={Cyclin/PCNA is the auxiliary protein of DNA polymerase-δ},
  author={R. Lopez Bravo and Rainer Frank and Patricia A. Blundell and Heather Macdonald-Bravo},
Identification of the cellular proteins whose expression is regulated during the cell cycle in normal cells is essential for understanding the mechanisms involved in the control of cell proliferation. A nuclear protein called cyclin of relative molecular mass 36,000 (Mr 36K), whose synthesis correlates with the proliferative state of the cell, has been identified in several cell types of human, mouse, hamster and avian origin1–5. The rate of cyclin synthesis is very low in quiescent cells and… CONTINUE READING