Cyclical expression of EBV latent membrane protein 1 in EBV-transformed B cells underpins heterogeneity of epitope presentation and CD8+ T cell recognition.

@article{Brooks2009CyclicalEO,
  title={Cyclical expression of EBV latent membrane protein 1 in EBV-transformed B cells underpins heterogeneity of epitope presentation and CD8+ T cell recognition.},
  author={Jill Mary Brooks and Seunghun Paul Lee and Alison M. Leese and Wendy Anne Thomas and Martin Phillip Rowe and A. B. Page Rickinson},
  journal={Journal of immunology},
  year={2009},
  volume={182 4},
  pages={
          1919-28
        }
}
CD8(+) T cells specific for EBV latent cycle epitopes can be reactivated in vitro by stimulating with the autologous EBV-transformed B lymphoblastoid cell line (LCL). The resultant CD8(+) clones kill epitope peptide-loaded targets, but frequently do not kill or show only low levels of lysis of the unmanipulated LCL in 5-h cytotoxicity assays. However, they reproducibly show clear LCL recognition in cytokine (IFN-gamma) release assays and inhibit LCL outgrowth in long-term coculture assays. We… CONTINUE READING
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