Cyclical change of hMSH2 protein expression in normal endometrium during the menstrual cycle and its overexpression in endometrial hyperplasia and sporadic endometrial carcinoma.

@article{Hamid2002CyclicalCO,
  title={Cyclical change of hMSH2 protein expression in normal endometrium during the menstrual cycle and its overexpression in endometrial hyperplasia and sporadic endometrial carcinoma.},
  author={Atia A Hamid and Masaki Mandai and Ikuo Konishi and Kanako Nanbu and Yuko Tsuruta and Takashi Kusakari and Masatoshi Kariya and Masato Kita and Shingo Fujii},
  journal={Cancer},
  year={2002},
  volume={94 4},
  pages={997-1005}
}
BACKGROUND The role of hMSH2 protein, one of the major DNA repair proteins, until now, had not been elucidated in terms of normal endometrial function during the menstrual cycle. The current study was designed to address this issue and to determine whether the expression of hMSH2 is altered in the course of endometrial carcinogenesis. METHODS Immunohistochemical reactivity with a monoclonal antibody against the hMSH2 protein was examined in endometrial tissue specimens from 45 patients with… CONTINUE READING