Cyclical action of the WASH complex: FAM21 and capping protein drive WASH recycling, not initial recruitment.

@article{Park2013CyclicalAO,
  title={Cyclical action of the WASH complex: FAM21 and capping protein drive WASH recycling, not initial recruitment.},
  author={Laura E Park and Peter A Thomason and Tobias Zech and Jason S. King and Douwe M Veltman and Michael Carnell and Seiji Ura and Laura M Machesky and Robert H Insall},
  journal={Developmental cell},
  year={2013},
  volume={24 2},
  pages={169-81}
}
WASH causes actin to polymerize on vesicles involved in retrograde traffic and exocytosis. It is found within a regulatory complex, but the physiological roles of the other four members are unknown. Here we present genetic analysis of the subunits' individual functions in Dictyostelium. Mutants in each subunit are completely blocked in exocytosis. All subunits except FAM21 are required to drive actin assembly on lysosomes. Without actin, lysosomes never recycle vacuolar-type H(+)-adenosine… CONTINUE READING
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