Cyclic thrombocytopenia associated with IgM anti-GPIIb-IIIa autoantibodies.

  title={Cyclic thrombocytopenia associated with IgM anti-GPIIb-IIIa autoantibodies.},
  author={Shinji Kosugi and Yoshiaki Tomiyama and Minoru Shiraga and Hirokazu Kashiwagi and Haruhiko Nakao and Yoshio Kanayama and Yoshiyuki Kurata and Yuji Matsuzawa},
  journal={British journal of haematology},
  volume={88 4},
We studied a female patient with cyclic fluctuation in platelet count following splenectomy for autoimmune thrombocytopenia. The cyclical fluctuation appeared to be in phase with her menstrual cycle and her platelet count was low during menses. Bone marrow examinations performed at the peak as well as the bottom of the platelet count showed normal or increased numbers of megakaryocytes. The patient's platelet count increased rapidly after intravenous gamma-globulin (IVIgG) therapy, suggesting… CONTINUE READING

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