Cyclic tetrapeptides via the ring contraction strategy: chemical techniques useful for their identification.

@article{Horton2008CyclicTV,
  title={Cyclic tetrapeptides via the ring contraction strategy: chemical techniques useful for their identification.},
  author={Douglas A. Horton and Gregory T. Bourne and Justin Coughlan and Sonya M Kaiser and Carolyn M. Jacobs and Alun Jones and Andreas R{\"u}hmann and Jill Y Turner and Mark L. Smythe},
  journal={Organic & biomolecular chemistry},
  year={2008},
  volume={6 8},
  pages={1386-95}
}
Cyclic tetrapeptides are a class of natural products that have been shown to have broad ranging biological activities and good pharmacokinetic properties. In order to synthesise these highly strained compounds a ring contraction strategy had previously been reported. This strategy was further optimised and a suite of techniques, including the Edman degradation and mass spectrometry/mass spectrometry, were developed to enable characterisation of cyclic tetrapeptide isomers. An NMR solution… CONTINUE READING

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