Cyclic tensile stretch on bovine articular chondrocytes inhibits protein kinase C activity.

@article{Fukuda1997CyclicTS,
  title={Cyclic tensile stretch on bovine articular chondrocytes inhibits protein kinase C activity.},
  author={Keiichi Fukuda and Sachie Asada and Fumio Kumano and Masahiro Saitoh and Kenichi Otani and Satoshi Tanaka},
  journal={The Journal of laboratory and clinical medicine},
  year={1997},
  volume={130 2},
  pages={209-15}
}
Osteoarthrosis, a common pathway of joint deterioration, is caused by mechanical stress loaded on articular cartilage. We previously demonstrated the involvement of protein kinase C (PKC) in the development of osteoarthritis in vitro. In this study, we examined the effect of mechanical stress on chondrocyte metabolism and the activity of PKC in vitro. Low frequency and magnitude of cyclic tensile stretch loaded on chondrocytes increased proteoglycan synthesis. However, high frequency and… CONTINUE READING