Cyclic tensile strain upregulates collagen synthesis in isolated tendon fascicles.

@article{Screen2005CyclicTS,
  title={Cyclic tensile strain upregulates collagen synthesis in isolated tendon fascicles.},
  author={Hazel R. C. Screen and Julia C Shelton and Dan L. Bader and David A Lee},
  journal={Biochemical and biophysical research communications},
  year={2005},
  volume={336 2},
  pages={424-9}
}
Mechanical stimulation has been implicated as an important regulatory factor in tendon homeostasis. In this study, a custom-designed tensile loading system was used to apply controlled mechanical stimulation to isolated tendon fascicles, in order to examine the effects of 5% cyclic tensile strain at 1 Hz on cell proliferation and matrix synthesis. Sample viability and gross structural composition were maintained over a 24 h loading period. Data demonstrated no statistically significant… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 35 extracted citations

The (dys)functional extracellular matrix.

Biochimica et biophysica acta • 2015
View 4 Excerpts
Highly Influenced

Zonal variation in primary cilia elongation correlates with localized biomechanical degradation in stress deprived tendon

Journal of orthopaedic research : official publication of the Orthopaedic Research Society • 2016
View 1 Excerpt

Tendon mechanobiology: Current knowledge and future research opportunities.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society • 2015

Similar Papers

Loading similar papers…