Cyclic tensile strain upregulates collagen synthesis in isolated tendon fascicles.

@article{Screen2005CyclicTS,
  title={Cyclic tensile strain upregulates collagen synthesis in isolated tendon fascicles.},
  author={Hazel R. C. Screen and Julia C Shelton and Dan L. Bader and Dong Hoon Lee},
  journal={Biochemical and biophysical research communications},
  year={2005},
  volume={336 2},
  pages={
          424-9
        }
}
Mechanical stimulation has been implicated as an important regulatory factor in tendon homeostasis. In this study, a custom-designed tensile loading system was used to apply controlled mechanical stimulation to isolated tendon fascicles, in order to examine the effects of 5% cyclic tensile strain at 1 Hz on cell proliferation and matrix synthesis. Sample viability and gross structural composition were maintained over a 24 h loading period. Data demonstrated no statistically significant… CONTINUE READING
BETA

Similar Papers

Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 49 CITATIONS

The (dys)functional extracellular matrix.

  • Biochimica et biophysica acta
  • 2015
VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

In vitro loading models for tendon mechanobiology.

  • Journal of orthopaedic research : official publication of the Orthopaedic Research Society
  • 2017