Cyclic sulfates as useful tools in the asymmetric synthesis of 1-aminocyclopropane-1-carboxylic acid derivatives

@inproceedings{Jakubowska2015CyclicSA,
  title={Cyclic sulfates as useful tools in the asymmetric synthesis of 1-aminocyclopropane-1-carboxylic acid derivatives},
  author={Anna Jakubowska and Grzegorz Żuchowski and Katarzyna Kulig},
  year={2015}
}
Abstract The enantiomers of 4-(2-methoxyethyl)-1,3,2-dioxathiolane-2,2-dioxide and 4-(methoxymethyl)-1,3,2-dioxathiolane-2,2-dioxide have been used as ‘epoxide-like’ synthons during the asymmetric alkylation of oxazinone-derived glycine equivalents. Using a fully stereoselective synthesis, eight stereoisomers of the spiro derivatives of the glycine equivalents were obtained. The relative configurations of the spiro compounds obtained were easily determined using nuclear magnetic resonance… CONTINUE READING

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