Cyclic stretch stimulates nitric oxide synthase-1-dependent peroxynitrite formation by neonatal rat pulmonary artery smooth muscle.

@article{Dick2013CyclicSS,
  title={Cyclic stretch stimulates nitric oxide synthase-1-dependent peroxynitrite formation by neonatal rat pulmonary artery smooth muscle.},
  author={Andrew S Dick and Julijana Ivanovska and Crystal Kantores and Rosetta Belcastro and A Keith Tanswell and Robert P Jankov},
  journal={Free radical biology & medicine},
  year={2013},
  volume={61},
  pages={310-9}
}
Peroxynitrite, the reaction product of nitric oxide and superoxide, contributes to the pathogenesis of chronic pulmonary hypertension in immature animals by stimulating proliferation of pulmonary arterial smooth muscle cells (PASMCs). Pulmonary vasoconstriction, secondary to hypoxia and other stimuli, leads to enhanced pulsatile stretch of cells in the vascular wall, particularly in smooth muscle, which we hypothesized would cause increased peroxynitrite generation. Our objectives in this study… CONTINUE READING
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