Cyclic stretch induces alveolar epithelial barrier dysfunction via calpain-mediated degradation of p120-catenin.

@article{Wang2011CyclicSI,
  title={Cyclic stretch induces alveolar epithelial barrier dysfunction via calpain-mediated degradation of p120-catenin.},
  author={Yuelan Wang and Richard D Minshall and David E. Schwartz and Guochang Hu},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2011},
  volume={301 2},
  pages={L197-206}
}
Lung hyperinflation is known to be an important contributing factor in the pathogenesis of ventilator-induced lung injury. Mechanical stretch causes epithelial barrier dysfunction and an increase in alveolar permeability, although the precise mechanisms have not been completely elucidated. p120-catenin is an adherens junction-associated protein that regulates cell-cell adhesion. In this study, we determined the role of p120-catenin in cyclic stretch-induced alveolar epithelial barrier… CONTINUE READING