Cyclic strain stimulates proliferative capacity, α2 and α5 integrin, gene marker expression by human articular chondrocytes propagated on flexible silicone membranes

@article{Lahiji2004CyclicSS,
  title={Cyclic strain stimulates proliferative capacity, α2 and α5 integrin, gene marker expression by human articular chondrocytes propagated on flexible silicone membranes},
  author={Kian Lahiji and A. E. Polotsky and David S. Hungerford and Carmelita G. Frondoza},
  journal={In Vitro Cellular & Developmental Biology - Animal},
  year={2004},
  volume={40},
  pages={138-142}
}
SummaryChondrocytes comprise less than 10% of cartilage tissue but are responsible for sensing and responding to mechanical stimuli imposed on the joint. However, the effect of mechanical signals at the cellular level is not yet fully defined. The purpose of this study was to test the hypothesis that mechanical stimulation in the form of cyclic strain modulates proliferative capacity and integrin expression of chondrocytes from osteoarthritic knee joints. Chondrocytes isolated from articular… CONTINUE READING

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