Cyclic strain induces vascular smooth muscle cell differentiation from murine embryonic mesenchymal progenitor cells.

@article{Riha2007CyclicSI,
  title={Cyclic strain induces vascular smooth muscle cell differentiation from murine embryonic mesenchymal progenitor cells.},
  author={Gordon M. Riha and Xinwen Wang and Hao Wang and Hong Chai and Hong Na Mu and Peter H Lin and Alan B. Lumsden and Qing’an Yao and Changyi Johnny Chen},
  journal={Surgery},
  year={2007},
  volume={141 3},
  pages={
          394-402
        }
}
BACKGROUND Hemodynamic forces play a crucial role in regulating vascular cell phenotype. However, the underlying molecular mechanisms are largely unknown. The objective of this study was to test our hypothesis that cyclic strain could affect smooth muscle cell (SMC) differentiation. METHODS A murine embryonic mesenchymal progenitor cell line (C3H/10T1/2) was cultured with or without cyclic strain for 6 days. Changes in cell morphology were studied with fluorescence dye Calcein-AM staining… CONTINUE READING
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