Cyclic strain dominates over microtopography in regulating cytoskeletal and focal adhesion remodeling of human mesenchymal stem cells.

@article{Doroudian2013CyclicSD,
  title={Cyclic strain dominates over microtopography in regulating cytoskeletal and focal adhesion remodeling of human mesenchymal stem cells.},
  author={Golnar Doroudian and Matthew W Curtis and Anjulie Gang and Brenda Russell},
  journal={Biochemical and biophysical research communications},
  year={2013},
  volume={430 3},
  pages={1040-6}
}
Human bone marrow-derived mesenchymal stem cell (hMSCs) function depends on chemical factors and also on the physical cues of the microenvironmental niche. Here, this physical microenvironment is recapitulated with controlled modes of mechanical strain applied to substrata containing three-dimensional features in order to analyze the effects on cell morphology, focal adhesion distribution, and gene expression. Ten percentage of strain at 1 Hz is delivered for 48 h to hMSCs cultured on flat… CONTINUE READING