Cyclic peptides as inhibitors of amyloid fibrillation.

  title={Cyclic peptides as inhibitors of amyloid fibrillation.},
  author={Jinghui Luo and Jan Pieter Abrahams},
  volume={20 9},
Many neurodegenerative diseases, like Parkinson's, Alzheimer's, or Huntington's disease, occur as a result of amyloid protein fibril formation and cell death induced by this process. Cyclic peptides (CPs) and their derivatives form a new class of powerful inhibitors that prevent amyloid fibrillation and decrease the cytotoxicity of aggregates. The strategies for designing CPs are described, with respect to their amino acid sequence and/or conformational similarity to amyloid fibrils. The… CONTINUE READING

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