Cyclic peptide inhibitors of HIV-1 integrase derived from the LEDGF/p75 protein.

Abstract

Restricting linear peptides to their bioactive conformation is an attractive way of improving their stability and activity. We used a cyclic peptide library with conformational diversity for selecting an active and stable peptide that mimics the structure and activity of the HIV-1 integrase (IN) binding loop from its cellular cofactor LEDGF/p75 (residues… (More)
DOI: 10.1016/j.bmc.2010.09.046

Topics

6 Figures and Tables

Cite this paper

@article{Hayouka2010CyclicPI, title={Cyclic peptide inhibitors of HIV-1 integrase derived from the LEDGF/p75 protein.}, author={Zvi Hayouka and Mattan Hurevich and Aviad Levin and Hadar Benyamini and Anat Iosub and Michal Maes and Deborah E. Shalev and Abraham Loyter and Chaim Gilon and Assaf Friedler}, journal={Bioorganic & medicinal chemistry}, year={2010}, volume={18 23}, pages={8388-95} }