Cyclic peptide helices: a hybrid beta-hairpin/beta-helical supersecondary structure.

Abstract

This communication describes the design and characterization of a new peptide motif that is a hybrid of beta-hairpin and beta-helical structures. This motif was supported by CD and IR spectrocopies in nonpolar organic solvents and was confirmed by NMR spectroscopy and structure calculations using NMR-derived restraints. The beta-hairpin/beta-helical motif represents a potentially attractive new structural template for a variety of possible applications in biomolecular design, such as ligands for macromolecular targets and building blocks for new protein architectures.

Cite this paper

@article{Sastry2006CyclicPH, title={Cyclic peptide helices: a hybrid beta-hairpin/beta-helical supersecondary structure.}, author={M. H. H. Sastry and Christopher D Brown and Gerhard Wagner and Thomas D. Clark}, journal={Journal of the American Chemical Society}, year={2006}, volume={128 33}, pages={10650-1} }