Cyclic oxidation and reduction of protein methionine residues is an important antioxidant mechanism

@article{Stadtman2002CyclicOA,
  title={Cyclic oxidation and reduction of protein methionine residues is an important antioxidant mechanism},
  author={Earl R. Stadtman and Jackob Moskovitz and Barbara S. Berlett and Rodney L Levine},
  journal={Molecular and Cellular Biochemistry},
  year={2002},
  volume={234},
  pages={3-9}
}
Almost all forms of reactive oxygen species (ROS) oxidize methionine residues of proteins to a mixture of the R- and S-isomers of methionine sulfoxide. Because organisms contain methionine sulfoxide reductases (Msr's) that can catalyze the thioredoxin-dependent reduction of the sulfoxides back to methionine, it was proposed that the cyclic oxidation… CONTINUE READING