Cyclic nucleotides depress action potentials in cultured aortic smooth muscle cells.

@article{Ousterhout1987CyclicND,
  title={Cyclic nucleotides depress action potentials in cultured aortic smooth muscle cells.},
  author={J M Ousterhout and Nick Sperelakis},
  journal={European journal of pharmacology},
  year={1987},
  volume={144 1},
  pages={7-14}
}
The effects of cyclic nucleotide analogs and related agents on the Ca2+ dependent action potentials of cultured rat aortic smooth muscle cells (reaggregates) were examined. The action potentials were elicited by electrical stimulation in the presence of tetraethylammonium (TEA, 5-15 mM). Superfusion of the aortic cells with analogs of cyclic AMP (dibutyryl or 8-bromo-cyclic AMP, 1 mM), isoproterenol (1-10 microM) and forskolin (1-10 microM) depressed and abolished the TEA-induced action… CONTINUE READING

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