Cyclic nucleotide signaling in polycystic kidney disease.

  title={Cyclic nucleotide signaling in polycystic kidney disease.},
  author={Xiaofang Wang and Christopher J. Ward and Peter C. Harris and Vicente E. Torres},
  journal={Kidney international},
  volume={77 2},
Increased levels of 3'-5'-cyclic adenosine monophosphate (cAMP) stimulate cell proliferation and fluid secretion in polycystic kidney disease. Levels of this molecule are more sensitive to inhibition of phosphodiesterases (PDEs), whose activity far exceeds the rate of cAMP synthesis by adenylyl cyclase. Several PDEs exist, and here we measured the activity and expression of PDE families, their isoforms, and the expression of downstream effectors of cAMP signaling in the kidneys of rodents with… CONTINUE READING