Cyclic nucleotide research — still expanding after half a century

@article{Beavo2002CyclicNR,
  title={Cyclic nucleotide research — still expanding after half a century},
  author={Joseph A. Beavo and Laurence L. Brunton},
  journal={Nature Reviews Molecular Cell Biology},
  year={2002},
  volume={3},
  pages={710-718}
}
Since the discovery in 1957 that cyclic AMP acts as a second messenger for the hormone adrenaline, interest in this molecule and its companion, cyclic GMP, has grown. Over a period of nearly 50 years, research into second messengers has provided a framework for understanding transmembrane signal transduction, receptor–effector coupling, protein-kinase cascades and downregulation of drug responsiveness. The breadth and impact of this work is reflected by five different Nobel prizes. 
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