Cyclic nucleotide phosphodiesterases.

@article{Essayan2001CyclicNP,
  title={Cyclic nucleotide phosphodiesterases.},
  author={D. Essayan},
  journal={The Journal of allergy and clinical immunology},
  year={2001},
  volume={108 5},
  pages={
          671-80
        }
}
  • D. Essayan
  • Published 2001
  • Biology, Medicine
  • The Journal of allergy and clinical immunology
Cyclic nucleotide second messengers (cAMP and cGMP) play a central role in signal transduction and regulation of physiologic responses. Their intracellular levels are controlled by the complex superfamily of cyclic nucleotide phosphodiesterase (PDE) enzymes. Continuing advances in our understanding of the molecular pharmacology of these enzymes has led to the development of selective inhibitors as therapeutic agents for disease states ranging from cancer and heart failure to depression and… Expand
500 Citations
Cyclic Nucleotide Phosphodiesterases
Cyclic Nucleotide Phosphodiesterases: Molecular Regulation to Clinical Use
  • 1,454
  • PDF
Cyclic nucleotide phosphodiesterase families in intracellular signaling and diabetes.
  • C. Lugnier
  • Chemistry, Medicine
  • Advances in experimental medicine and biology
  • 2001
  • 5
Phosphodiesterase 5 mechanisms and therapeutic applications.
  • A. Burnett
  • Medicine
  • The American journal of cardiology
  • 2005
  • 55
Type 5 phosphodiesterase inhibition: the focus shifts to the heart.
  • 14
Cyclic nucleotide analogs as biochemical tools and prospective drugs.
  • 220
Cyclic nucleotide phosphodiesterase inhibitors: possible therapeutic drugs for female fertility regulation.
  • 1
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 133 REFERENCES
Cyclic nucleotide phosphodiesterase (PDE) inhibitors and immunomodulation.
  • D. Essayan
  • Biology, Medicine
  • Biochemical pharmacology
  • 1999
  • 122
Cyclic nucleotide phosphodiesterases: relating structure and function.
  • 544
Cyclic nucleotide-dependent protein kinases: intracellular receptors for cAMP and cGMP action.
  • 306
The molecular biology of cyclic nucleotide phosphodiesterases.
  • M. Conti, S. L. Jin
  • Biology, Medicine
  • Progress in nucleic acid research and molecular biology
  • 1999
  • 437
Regulation and function of the cyclic nucleotide phosphodiesterase (PDE3) gene family.
  • 197
Cyclic GMP-dependent protein kinases: understanding in vivo functions by gene targeting.
  • P. Ruth
  • Biology, Medicine
  • Pharmacology & therapeutics
  • 1999
  • 81
Cloning and characterization of a cAMP-specific cyclic nucleotide phosphodiesterase.
  • 251
  • PDF
Structure, Mechanism, and Regulation of Mammalian Adenylyl Cyclase*
  • J. Hurley
  • Chemistry, Medicine
  • The Journal of Biological Chemistry
  • 1999
  • 243
  • PDF
...
1
2
3
4
5
...