Cyclic nucleotide phosphodiesterases.

D. Essayan

DOI:10.1067/MAI.2001.119555

Corpus ID: 21528985

Cyclic nucleotide phosphodiesterases.

@article{Essayan2001CyclicNP,
  title={Cyclic nucleotide phosphodiesterases.},
  author={D. Essayan},
  journal={The Journal of allergy and clinical immunology},
  year={2001},
  volume={108 5},
  pages={
          671-80
        }
}

D. Essayan

Published 2001

Medicine

The Journal of allergy and clinical immunology

Cyclic nucleotide second messengers (cAMP and cGMP) play a central role in signal transduction and regulation of physiologic responses. Their intracellular levels are controlled by the complex superfamily of cyclic nucleotide phosphodiesterase (PDE) enzymes. Continuing advances in our understanding of the molecular pharmacology of these enzymes has led to the development of selective inhibitors as therapeutic agents for disease states ranging from cancer and heart failure to depression and… CONTINUE READING

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