Cyclic nucleotide phosphodiesterases.

@article{Essayan2001CyclicNP,
  title={Cyclic nucleotide phosphodiesterases.},
  author={D. Essayan},
  journal={The Journal of allergy and clinical immunology},
  year={2001},
  volume={108 5},
  pages={
          671-80
        }
}
  • D. Essayan
  • Published 2001
  • Medicine
  • The Journal of allergy and clinical immunology
  • Cyclic nucleotide second messengers (cAMP and cGMP) play a central role in signal transduction and regulation of physiologic responses. Their intracellular levels are controlled by the complex superfamily of cyclic nucleotide phosphodiesterase (PDE) enzymes. Continuing advances in our understanding of the molecular pharmacology of these enzymes has led to the development of selective inhibitors as therapeutic agents for disease states ranging from cancer and heart failure to depression and… CONTINUE READING
    Cyclic Nucleotide Phosphodiesterases

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