Cyclic nucleotide phosphodiesterases.
@article{Essayan2001CyclicNP, title={Cyclic nucleotide phosphodiesterases.}, author={David M. Essayan}, journal={The Journal of allergy and clinical immunology}, year={2001}, volume={108 5}, pages={ 671-80 } }
Cyclic nucleotide second messengers (cAMP and cGMP) play a central role in signal transduction and regulation of physiologic responses. Their intracellular levels are controlled by the complex superfamily of cyclic nucleotide phosphodiesterase (PDE) enzymes. Continuing advances in our understanding of the molecular pharmacology of these enzymes has led to the development of selective inhibitors as therapeutic agents for disease states ranging from cancer and heart failure to depression and…
525 Citations
Cyclic Nucleotide Phosphodiesterases: Molecular Regulation to Clinical Use
- BiologyPharmacological Reviews
- 2006
Basic biochemical properties, cellular regulation, expression patterns, and physiological functions of the different PDE isoforms will be discussed and how these properties relate to the current and future development of PDE inhibitors as pharmacological agents is especially considered.
Cyclic nucleotide phosphodiesterase families in intracellular signaling and diabetes.
- BiologyAdvances in experimental medicine and biology
- 2001
The altered PDE family may represent new classes of drug targets for diabetes since it was reported that insulin-induced phosphorylation activates PDE3 and that PDE4 inhibitors may prevent installation of diabetes (Liang et al., 1998).
Cyclic nucleotide phosphodiesterases as targets for treatment of haematological malignancies.
- Biology, MedicineThe Biochemical journal
- 2006
This review summarizes the expression and function of PDEs in normal haematopoietic cells and the evidence that family-specific inhibitors will be therapeutically useful in myeloid and lymphoid malignancies.
Phosphodiesterase 5 mechanisms and therapeutic applications.
- BiologyThe American journal of cardiology
- 2005
Type 5 phosphodiesterase inhibition: the focus shifts to the heart.
- BiologyCirculation
- 2005
Load-independent measures of contractility are used to assess the myocardial effects of an agent (sildenafil) that increases intracellular cGMP levels by inhibiting its degradation.
Cyclic nucleotide analogs as biochemical tools and prospective drugs.
- Biology, ChemistryPharmacology & therapeutics
- 2000
PDE4 cAMP phosphodiesterases: modular enzymes that orchestrate signalling cross-talk, desensitization and compartmentalization.
- Biology, ChemistryThe Biochemical journal
- 2003
PDE4 enzymes stand at a crossroads that allows them to integrate various signalling pathways with that of cAMP in spatially distinct compartments, and the recent elucidation of the structure of the PDE4 catalytic unit allows for molecular insight into the mode of catalysis as well as substrate and inhibitor selectivity.
Cyclic nucleotide phosphodiesterase inhibitors: possible therapeutic drugs for female fertility regulation.
- Biology, ChemistryEuropean journal of pharmacology
- 2020
Assay and purification of calmodulin-dependent cyclic nucleotide phosphodiesterase and isozyme separation.
- BiologyMethods in molecular biology
- 2005
This work has shown that the CaM-dependent cyclic nucleotide phosphodiesterase (CaMPDE) is one of the most intensively studied and best characterized PDEs.
EFFECT OF PHOSPHODIESTERASE 4 (PDE4) INHIBITORS ON EOTAXIN EXPRESSION IN HUMAN BRONCHIAL EPITHELIAL CELLS
- Biology, Medicine
- 2011
PDE4 inhibitors increase cyclic adenosine monophosphate level in cells and inhibit various stages of the inflammatory process, and eotaxins are the strongest chemotactic agents for eosinophils.
References
SHOWING 1-10 OF 133 REFERENCES
Cyclic nucleotide phosphodiesterase (PDE) inhibitors and immunomodulation.
- Biology, ChemistryBiochemical pharmacology
- 1999
Cyclic nucleotide phosphodiesterases: relating structure and function.
- BiologyProgress in nucleic acid research and molecular biology
- 2001
Cyclic nucleotide-dependent protein kinases: intracellular receptors for cAMP and cGMP action.
- BiologyCritical reviews in clinical laboratory sciences
- 1999
This review summarizes many studies that have contributed significantly to an improved understanding of the catalytic, regulatory, and structural properties of these protein kinases and provides insights into the mechanisms by which these enzymes produce their specific physiological effects.
The molecular biology of cyclic nucleotide phosphodiesterases.
- BiologyProgress in nucleic acid research and molecular biology
- 1999
Regulation and function of the cyclic nucleotide phosphodiesterase (PDE3) gene family.
- BiologyProgress in nucleic acid research and molecular biology
- 2001
Atomic structure of PDE4: insights into phosphodiesterase mechanism and specificity.
- Chemistry, BiologyScience
- 2000
The three-dimensional structure of the catalytic domain of phosphodiesterase 4B2B to 1.77 angstrom resolution suggests the mechanism of action and basis for specificity and will provide a framework for structure-assisted drug design for members of the phosphodiedterase family.
Phosphodiesterase II, the cGMP-activatable cyclic nucleotide phosphodiesterase, regulates cyclic AMP metabolism in PC12 cells.
- BiologyMolecular pharmacology
- 1991
Analysis of cyclic nucleotide phosphodiesterase (PDE) activity in cellular fractions from cultured rat pheochromocytoma (PC12) cells has shown that the predominant hydrolytic activity in both…
Cyclic GMP-dependent protein kinases: understanding in vivo functions by gene targeting.
- BiologyPharmacology & therapeutics
- 1999
Cloning and characterization of a cAMP-specific cyclic nucleotide phosphodiesterase.
- BiologyProceedings of the National Academy of Sciences of the United States of America
- 1998
Cl cloning and characterization of a novel cAMP-specific PDE from mouse testis shows that PDE8 is expressed in the seminiferous epithelium in a stage-specific manner, and clearly represents a previously unknown PDE gene family designated as Pde8.
Structure, Mechanism, and Regulation of Mammalian Adenylyl Cyclase*
- Biology, ChemistryThe Journal of Biological Chemistry
- 1999
The essentials of catalysis are described and then how these elements are controlled by each of the major regulators are considered: free metal ions, P-site inhibitors, forskolin, G-proteins, Ca/calmodulin, and protein phosphorylation.