Cyclic nucleotide phosphodiesterases: potential therapeutic targets for alcohol use disorder

@article{Wen2018CyclicNP,
  title={Cyclic nucleotide phosphodiesterases: potential therapeutic targets for alcohol use disorder},
  author={Rui-Ting Wen and Fang-Fang Zhang and Han Zhang},
  journal={Psychopharmacology},
  year={2018},
  volume={235},
  pages={1793-1805}
}
Alcohol use disorder (AUD), which combines the criteria of both alcohol abuse and dependence, contributes as an important causal factor to multiple health and social problems. Given the limitation of current treatments, novel medications for AUD are needed to better control alcohol consumption and maintain abstinence. It has been well established that the intracellular signal transduction mediated by the second messengers cyclic AMP (cAMP) and cyclic GMP (cGMP) crucially underlies the genetic… CONTINUE READING
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