Cyclic nucleotide phosphodiesterases: pharmacology, biochemistry and function.

@article{Thompson1991CyclicNP,
  title={Cyclic nucleotide phosphodiesterases: pharmacology, biochemistry and function.},
  author={William J. Thompson},
  journal={Pharmacology & therapeutics},
  year={1991},
  volume={51 1},
  pages={13-33}
}
This article is a review of cyclic nucleotide phosphodiesterase(s) (CN PDE) from the point of view of the relationships between the newer aspects of the complex enzymology of CN PDE and recent major advances in CN PDE pharmacology. A consolidation of isozyme nomenclature to the proposed family designations is recommended. Emphasis is placed on the importance of defining the subcellular localization of isozymes expressed in a given tissue and cyclic GMP substrate and regulatory roles in CN PDE… CONTINUE READING