Cyclic nucleotide phosphodiesterase in human bronchial epithelial cells: characterization of isoenzymes and functional effects of PDE inhibitors.

@article{Dent1998CyclicNP,
  title={Cyclic nucleotide phosphodiesterase in human bronchial epithelial cells: characterization of isoenzymes and functional effects of PDE inhibitors.},
  author={Gordon Dent and Steven R White and Hermann Tenor and K. Bodtke and Christian Schudt and Alan R. Leff and H. Magnussen and Klaus Friedrich Rabe},
  journal={Pulmonary pharmacology & therapeutics},
  year={1998},
  volume={11 1},
  pages={47-56}
}
Cyclic AMP (adenosine 3':5'-cyclic monophosphate, cAMP) is an intracellular second messenger that mediates the actions of endogenous hormones and neurotransmitters and also of drugs such as beta-adrenoceptor agonists. The presence of functional beta-adrenoceptors on human airway epithelial cells has been demonstrated but the expression of the cAMP-metabolizing enzyme, cyclic nucleotide phosphodiesterase (PDE) in these cells has not been studied. We investigated the profile of activity of the… CONTINUE READING

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